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Home / Professionals / Services / Gene Therapy Research Unit

Gene Therapy Research Unit

A joint initiative of The Children's Hospital at Westmead and Children's Medical Research Institute

Main : Projects : Publications : Staff : Contact

Publications

Curtin J.A., Dane A.P., Swanson A., Alexander I.E. and Ginn S.L. (2008) Bi-directional promoter interference between two widely used internal heterologous promoters in a late-generation lentiviral construct. Gene Therapy 15(5):384-390, epub 24th January, 2008.

Baoutina, A., Alexander, I.E., Rasko, J.E.J., and Emslie, K.R. (2008). Developing strategies for detection of gene doping. Journal of Gene Medicine 10(1):3-20.

Baoutina, A., Alexander, I.E., Rasko, J.E.J., and Emslie, K.R. (2007). Potential use of gene therapy in athletic performance enhancement. Molecular Therapy 15(10):1751-1766, epub 7th August, 2007.

Ganesan P.L., Alexander S.I., Watson D., Logan G.J., Zhang G.Y., and Alexander I.E. (2007) Robust anti-tumor immunity and memory in Rag-1-deficient mice following adoptive transfer of cytokine-primed splenocytes and tumor CD80 expression. Cancer Immunology Immunotherapy 56(12):1955-1965, epub 5th June, 2007.

Deichmann A., Hacein-Bey Abina S., Schmidt M., Garrigue A., Brugman M., Hu J., Glimm H., Gyapay G., Prum B., Fraser C.C., Fischer N., Schwarzwaelder K., Siegler M-L., de Ridder D., Pike-Overzet K., Howe S.J., Thrasher A.J., Wagemaker G., Abel U., Staal F., Delabesse E., Villeval J-L., Aronow B., Hue C., Prinz C., Wissler M., Klanke C., Weissenbach J., Alexander I., Fischer A., von Kalle C. and Cavazzana-Calvo M. (2007) Vector integration is non-random, clustered and influences the in vivo fate of lymphopoiesis in SCID-X1 gene therapy. Journal of Clinical Investigation 117(8):2225-2232.

Kizana E., Chang C.Y., Cingolani E., Ramirez-Correa G.A., Sekar R.B., Abraham M.R., Ginn S.L., Tung L., Alexander I.E. and Marban E. (2007) Gene Transfer of Connexin43 Mutants Attenuates Coupling in Cardiomyocytes: Novel Basis for Modulation of Cardiac Conduction by Gene Therapy. Circulation Research 100(11):1597-1604, epub 10th May, 2007.

Smyth C.M., Ginn S.L., Deakin C.T., Logan G.J. and Alexander I.E. (2007) Limiting c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood 110(1):91-98, epub 15th March 2007.

Yu Z-Y., McKay K., van Asperen P., Zheng M., Fleming J., Ginn S.L., Kizana E., Latham M., Feneley M.P., Kirkland P.D., Lumbers E.R. and Alexander I.E. (2007) Lentivirus vector-mediated gene transfer to the developing bronchiolar airway epithelium in the fetal lamb. Journal of Gene Medicine 9(6):429-439, epub 5th April, 2007.

Cooper S.T., Kizana E., Yates J.D., Lo H.P., Yang N., Wu Z.H., Alexander I.E. and North K.N. (2007) Dystrophinopathy carrier determination and dectection of protein deficie in muscular dystrophy using lentiviral MyoD-forced myogenesis. Neuromuscular Disorders 17(4):276-284, epub 13th February 2007.

Logan G.J., Wang L., Zheng M., Cunningham S.C., Coppel R.L. and Alexander I.E. (2007) AAV vectors encoding malarial antigens stimulate transgene-specific immunity but do not protect from parasite infection. Vaccine 25(6):1014-1022, epub 9th October 2006.

Kizana E., Ginn S.L., Smyth C., Boyd A., Thomas S.P., Allen D.G., Ross D.L., Alexander I.E. (2006) Fibroblasts modulate cardiomyocyte excitability: Implications for Cardiac Gene Therapy. Gene Therapy 13(22):1611-1615, epub 13th July 2006.

Kramer B.A., Lemckert F.A., Alexander I.E., Gunning P.W. and McCowage G.B. (2006) Characterisation of a P140K mutant O6-Methyl-Guanine-Methyl-Transferase (MGMT) expressing transgenic mouse line with drug selectable bone marrow. Journal of Gene Medicine 8(9):1071-1085, epub 4th April 2006.

Wang Y.M., Zhang G.Y., Wang Y., Hu M., Wu H., Watson D., Hori S., Alexander I.E., Harris D.C.H., and Alexander S.I. (2006) Foxp3-transduced polyclonal regulatory T cells protect against chronic renal injury from Adriamycin. J Am Soc Nephrol. 17(3):697-706, epub 8th February 2006.

Trent R.J.A. and Alexander I.E. (2006) Gene Therapy in Sport. British Journal of Sports Medicine 40(1):4-5.

Mitchell J.J., Wilcken B., Alexander I., Ellaway C., O'Grady H., Wiley V., Earl J. and Christodoulou J. (2005) Tetrahydrobiopterin Responsive Phenylketonuria: The New South Wales Experience. Molecular Genetics and Metabolism 86S:81-85, epub 8th August 2005.

Fleming J., Spinoulas A., Zheng M., Cunningham S.C., Ginn S.L., McQuilty R.C., Rowe P.B. and Alexander I.E. (2005) Partial correction of sensitivity to oxidant stress in FRDA patient fibroblasts by frataxin-encoding adeno-associated virus and lentivirus vectors. Human Gene Therapy 16(8):947-956, epub 24th June 2005.

Ginn S.L., Curtin J.A., Kramer B., Smyth C., Wong M., Kakakios A., McCowage G., Watson D., Alexander S.I., Latham M., Cunningham S., Zheng M., Hobson L., Rowe P.B., Fischer A., Cavazzana-Calvo M., Hacein-Bey-Abina S. and Alexander I.E. (2005) Treatment of an infant with X-linked severe combined immunodeficiency (SCID-X1) by gene therapy in Australia. Medical Journal of Australia 182(9):458-463.

Kizana E., Ginn S.L., Allen D.G., Ross D.L. and Alexander I.E. (2005) Fibroblasts can be Genetically Modified to Produce Excitable Cells Capable of Electrical Coupling. Circulation 111(4):394-398.

Smyth C.M., Logan G., Boadle R., Rowe P.B., Smythe J.A. and Alexander I.E. (2005) Differential subcellular localisation of CD86 in human PBMC-derived macrophages and DCs, and ultrastructural characterisation by immuno-electron microscopy. International Immunology 17(2):123-132, epub 27th Dec 2004.

Trent R.J.A. and Alexander I.E. (2004) Gene Therapy: Applications and Progress Towards the Clinic. Int Med J 34(11):621-625.

Cooper S.T., Maxwell A.L., Kizana E., Ghoddusi M., Hardeman E.C., Alexander I.E., Allen D.G. and North K.N. (2004) C2C12 co-culture on a fibroblast substratum enables sustained survival of contractile, highly differentiated myotubes with peripheral nuclei and adult fast myosin expression. Cell Motility and the Cytoskeleton 58(3):200-11.

Ginn S.L., Smyth C., Wong M., Bennetts B. and Alexander I.E. (2004) A Novel Splice-Site Mutation in the Gene for the Common Gamma ( c) Chain Results in Severe Combined Immunodeficiency (SCID-X1) with an NK+ Phenotype. Human Mutation 23(5):522-533.

Logan G.J., Spinoulas A., Alexander S.I., Smythe J.A. and Alexander I.E. (2004) CD4 expression on EL4 cells as an epiphenomenon of retroviral transduction and selection. Immunology and Cell Biology 82(2):132-135.

Hacein-Bey-Abina S, Von Kalle C, Schmidt M, McCormack MP, Wulffraat N, Leboulch P, Lim A, Osborne CS, Pawliuk R, Morillon E, Sorensen R, Forster A, Fraser P, Cohen JI, de Saint Basile G, Alexander I, Wintergerst U, Frebourg T, Aurias A, Stoppa-Lyonnet D, Romana S, Radford-Weiss I, Gross F, Valensi F, Delabesse E, Macintyre E, Sigaux F, Soulier J, Leiva LE, Wissler M, Prinz C, Rabbitts TH, Le Deist F, Fischer A, Cavazzana-Calvo M (2003) LMO2-associated clonal T cell proliferation in two patients after gene therapy for SCID-X1 [ c deficiency]. Science Oct 17;302(5644):415-9.

Kizana E. and Alexander I.E. (2003) Cardiac Gene Therapy:Therapeutic Potential and Current Progress. Curr Gene Ther. 3(5):418-51.

Ginn S.L., Fleming J., Rowe P.B.. and Alexander I.E. (2003) Promoter Interference Mediated by the U3 Region in Early-Generation HIV-1-Derived Lentivirus Vectors Can Influence Detection of Transgene Expression in a Cell-Type and Species-Specific Manner. Human Gene Therapy 14(12):1127-1138.

Ginn S.L., Fleming J., Curtin J.A. and Alexander I.E. (2003) Gene Therapy: A Roller-Coaster Ride. Today's Life Science 15(1):26-29 Invited review.

Fleming J., Ginn S.L. and Alexander I.E. (2003) Transduction of Ex Vivo Cultures Through Lentivirus Vectors. VI: Dorsal Root Ganglia Sensory Neurons. In: Lentivirus Gene Engineering Protocols, Humana Press, New Jersey.

Alexander I.E. (2002) Australasian Gene Therapy Society kicks off. J Gene Med. 2002 Jan-Feb;4(1):4. (Editorial)

Logan G.J., Smyth C.M.F., Earl J.W., Zaikina I., Rowe P.B., Smythe J.A. and Alexander I.E. (2002) HeLa cells co-cultured with peripheral blood lymphocytes acquire an immuno-inhibitory phenotype through up-regulation of indoleamine 2,3-dioxygenase (IDO) activity. Immunology 105(4):478-487.

Fleming J., Ginn S.L., Weinberger R.P., Trahair T.N., Smythe J.A. and Alexander I.E. (2001) Adeno-associated virus and lentivirus vectors mediate efficient and sustained transduction of cultured mouse and human dorsal root ganglia sensory neurons. Human Gene Therapy 12(1):77-86.

Main : Projects : Publications : Staff : Contact